Personnel: Main Research Scientist L. Tsiklauri; Senior Research Scientist D. Lagazidze; Research Scientist M. Orjonikidze; Research Scientist A. Janezashvili;
Objective: Development optimal formulations and laboratory technologies for drug dosage forms based on biologically active substances of herbal, mineral and synthetic origin.
Tasks:
1. Development of modern technological bases for receiving medicinal preparations from herbal and mineral sources of Georgia
2. Elaboration of optimal formulations and technologies for traditional and modern nanotechnology targeted drugs based on complex experimental and theoretical researches and optimization existing formulations.
3. Investigation of technological, biopharmaceutical and pharmacokinetic factors
4. Stability study of developed medicinal preparations
5. Preparation of normative - technical documentation.
History.
The direction of Pharmaceutical Technology has been operating since 1948 at the Institute. The priority of the research courses from that time was to expand the usege potential of Georgian bentonite clay in pharmacy, medicine and cosmetics. Bentonite clay preparations: “Tikha Ascane”, “Ascancol”, “Bentobol”, Baby powder “Baia” and other drugs for various usage containing “Medicinal Tannin”, “Platyphyllin Hydrotartrate”, “Colchicine” and “Colchamine” were developed in the department. On the bases of “Tikha Ascane” were elaborated Emulsion and suspension type semisolids and dry ointment concentrates. The possibility of regulating the degree of swelling of “Tikha Ascane” particles in absorption bases are studied by incorporating different emulsifiers. New formulations and technologies have been developed for the semisolid bases and were investigated their rheological, technological, resorptive and thixotropic characteristics, standardization methods were elaborated, and etc.
In 1999 the group of authors led by Prof. G. Tsagareishvili was awarded by the Academician A. Tvalchrelidze Prize for the Work Cycle: "Creating New Medicinal Products Using Georgian Bentonite Clays".
1 doctoral and 4 PhD thesis were defined, 11 inventor's certificate and patents has been obtained, 9 monographs, 97 scientific articles, abstracts were published.
Scientific directions.
1. Optimization of traditional technologies for obtaining active substances and medicinal preparations proposed by the Institute and creation their technical documentation:
A) Development of "Fatsiflogin" ointment technology and evaluation pharmacological effect of elaborated dosage form.
2. Development of optimal formulations and technologies for drug dosage forms and nanodelivery systems, investigation their bioavailability:
A) To investigate the hydrophilic / hydrophobic compounds intercalation and cationic exchange capabilities, swelling ability and other characteristics of “Tikha Ascane”, in order to develope bentonite based drug delivery systems.
B) Incorporation of robinin into nanoparticulate drug delivery system.
C) Develop liposomal form for original drug, “Leucobetin”, containing alkaloids from the root of Vinca herbacea Walds et kit.
Research Methodologies.
Modern pharmacopoeial methods are used in the studies:
Technological (extraction, lyophilization, centrifugation, traditional and nano based technologies for preparation dosage forms, etc.)
Physicochemical analysis (chromatographic, spectrophotometric, potentiometric, rheological), biopharmaceutical (dialysis, diffusion) and others methods for quality control of active substances and drug dosage forms.
Study direction.
Conducting the works stipulated by the Educational - Industrial Practice Program of TSMU Pharmacy Students
Expert-consulting direction. Expertise PhD research programs and doctoral thesis.
10 years results.
- Nano-particulate drug delivery system (pegylated nanoliposomes) was elaborated for “Vingerbin”; quantitative analysis methods are developed for Vingerbine and Flaronin in biological fluids; the technological parameters of active substances of Fatsiflogin and Tribusponin have been studied and tablets preparation technologies by direct compression methods are proposed; biopharmaceutical properties of Flaronin, Vingerbine and Fatsiflogin were investigated (bioavailability, interaction with biotransporters),
Optimal formulations and technologies are elaborated for rectal suppositories and spray, containing Papain; the stability of formulations were studied.
-Proposed zero-lose technology for obtaining of alcoholic and oily extracts from Calendula officinalis L, based on which vaginal suppositories are developed and the quality parameters and norms were established.
- Technologies for preparation granules and syrup from dry extract of Cephalaria were developed; the pharmacological efficacy of dosage forms is proved by in vivo methods.
- A new prolonged release suppository base containing bentonite ("Tikha Ascane ") has been recommended.
