Personnel: Principal scientific researcher, Z. Kemoklidze; Senior scientific researcher - V. Mshvildadze; Senior scientific researcher - T. Korkotadze.
History: The Direction of Terpene compounds separated from the Laboratory of Phytochemistry of the TSMU I. Kutateladze Institute of Pharmacochemistry Institute of Pharmacochemistry in 2006 as The Laboratory of Triterpene compounds and Doctor Genry Deanosidze a laureate of the State Prize,was appointed as the head of the new unit. He led the lab - until 2018. Since 2014, the lab has changed its name to The Direction of Terpene compounds and still operates under this name today.
The aim The Direction of Terpene compounds:
Phytochemical study of triterpene (terpene) compounds of native and cultivated potentially medicinal plant raw materials of Georgia for their future therapeutic and preventive use. Study of the Georgian flora and it’s biologically active compounds - terpenes, for their further application in the field of medicine, perfumery and various fields of public use.
Tasks:
Isolation of biologically active extracts, enriched fractions and individual substances from terpene-containing plants.
Obtaining medicinal substances from plants containing terpenes and development of medications on their basis.
Standardization of developed medicinal substances and medications and the development of their technical documentation.
Scientific directions: Phytochemistry, Pharmacognosy.
Research methodology: Research carried out by the Direction of Terpene compounds compounds is of fundamental and applied nature. It includes the phytochemical study and comparison of different organs of plants of the Georgian flora, their phytochemical characterization, development of active substances on their basis, study of their safety etc., which will allow the creation of new, effective, plant based dosage forms.
Conditions of extraction, fractionation of extract and separation of individual components from plant raw materials are used to optimize phytochemical studies;
Specifically, modern chromatographic (column, low-pressure liquid and HPLC using various adsorbents, such as silica gel, polyamide, Diaion HP20, sephadex LH20, reversed-phase RP18) and spectral analysis methods such as: Nuclear Magnetic Resonance (NMR) and Mass Spectrometry ).
Curriculum: In recent years, the direction of terpene compounds, along with other directions of the Institute of Pharmacochemistry, has been actively involved in the training of undergraduate and postgraduate students of the Faculty of Pharmacy at Tbilisi State Medical University.
Field of Expertise: Research staff The Direction of Terpene compounds often serves as expert consultants for doctoral and master's thesis in the field of pharmacy.
Results:
More than 200 plants of Georgian flora have undergone preliminary phytochemical analysis
12 species were thoroughly studied in respect for triterpene saponin content; More than 100 individual substances were separated and classified; out of these over 30 were of novel structure.
The main results are published in the form of 2 monographs and more than 200 scientific articles. 25 copyrights and patents have been obtained.
Medications:
Cavsuron drops, syrup and tablets - obtained from the leaves of ivy; Characterized by bronchospasmolytic activity, used in the treatment of diseases of the upper respiratory tract
Fatsiflogin - an original, non-steroidal anti-rheumatic drug (tablets) - derived from the triterpene glycosides of the leaves of the Japanese Fatsia, which has anti-inflammatory, analgesic and antipyretic effects.
Epicef - a biologically active extract against seizures.
Cyclasit – A substance for the treatment sinusitis, developed from Cyclamen tubers
"PS-551" - a patentable substance.
List of papers 2015-2019:
1.Кемоклидзе З. С., Деканосидзе Г.Е., Кемертелидзе Э.П. Препарат Фатсифлогин из растения Fatsia japonica (Thunb) Decnе et Planch. - Фатсии японской культивированной в Грузи“ RS GLOBAL Science Reviu”6(13), vol.3, Iuly 2018. 23-25.
2. 3. Кемертелидзе Э.П., Деканосидзе Г.Е., Мшвилдадзе В.Д., Табатадзе Н.А., Кемоклидзе З. С., Табидзе Б.В Химический состав и фармакологическая эффективность тритерпеновых гликозидов некоторых растений, произрастающих в Грузии. Монография. Национальная Академи наук Грузии Институт фармакохимии И.Г. Кутателадзе ТГМУТбилиси.2018. 285 С. .
3. 3..Кемоклидзе З. С., Деканосидзе Г.Е., Кемертелидзе Э.П. „БИОЛОГИЧЕСКИ АКТИВНЫЕ ТРИТЕРПЕНОВЫЕ ГЛИКОЗИДЫ КУЛЬТИВИРОВАННОЙ В ГРУЗИИ FATSIA JAPONICA (THUNB) DECNE ET PLANCH -ФАТСИИ ЯПОНСКОЙ“ Научно-практический журнал “Вопросы биологической, медицинской и фармацевтической химии“ №10,2018. 15-18.
4. ზ. ქემოკლიძე, მ. გეთია, ნ.გორგასლიძე. ფაციფლოგინის ტაბლეტებიდან მოქმედი ნივთიერების კონცენტრაციის დინამიკის ანალიზი ფარმაკოთერაპიის ოპტიმიზაციისათვის. „ექსპერიმენტული და კლინიკური მედიცინა“# 5. 2018. 53-54.
5 Getia , V. Mshvildadze , A. Pichette ,G. Dekanosidze , Z. Kemoklidze. Development of Analytical Procedure for the Quantification of “Fatsiflogin”. IOS Journal of Pharmacy. 2017. 7(3), pp. 96-99.
6. K. Mchedlidze, M. Churadze, J. Aneli, G. Moshiashvili and V. Mshvildadze. Anatomical structure of the stem and leaf of Daphne glomerata Lam. Journal of Pharmacognosy and Phytochemistry. 2019, 8(4), 3241-3244.
7 E.Kemertelidze, G. Dekanosidze, V. Mshvildadze, N. Tabatadze, Z. Kemoklidze, B.Tabidze. Chemical composition and pharmaceutical effectiveness of triterpene glycosides of certain plants growing in Georgia. Monograph, 2018, Georgian National Academy of Sciences, Tbilisi, Georgia.
8. . Lavoie S, Gauthier C, Mshvildadze V, Legault J, Roger B, Pichette A. DFT Calculations and ROESY NMR Data for the Diastereochemical Characterization of Cytotoxic Tetraterpenoids from the Oleoresin of Abies balsamea. J. Nat. Prod. 2015, 78, 2896−2907.
9..Malkhaz Getia , Vakhtang Mshvildadze , Genri Dekanosidze and André Pichette. Quantification of a crude extract from Hedera colchica. International Journal of Pharmaceutical Sciences and Research. 2015. Vol. 6, Issue 9, pp. 3836-3840.
10. Serge Lavoie, Charles Gauthier, Jean Legault, Vakhtang Mshvildadze and André Pichette. Diastereoisomeric tetraterpenes from Abies balsamea oleoresin. Phytochemical Society of Europe, “Trends in Natural Products Research”, June 23 –25, 2014 | Olomouc, Czec Republic.
